Country
Deadline
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Procurement Summary
Summary: Evaluation of Microbiome-Relevant Biomarkers and in Vitro Models for Xenobiotic Risk Assessment
Deadline: 12 Mar 2026
PostingDate: 26 Jan 2026
Other Information
Notice Type: Tender
TPD Ref No.: 134411223
Document Ref. No.: 54146-2026
Tender Value: EUR 300000
Document Fees: Refer Document
Purchaser's Detail
Purchaser: EUROPEAN FOOD SAFETY AUTHORITY
Address: EFSA.ED.CSO - Chief Scientist Office
Town: Parma
NUTS-Code: ITH52
Postal Code: I-43126
Phone: +39 0521 036 111
Email: efsaprocurement@efsa.europa.eu
URL: https://www.efsa.europa.eu
Tender Details
Addressing a key knowledge gap identified in EFSA's Gut Microbiome Roadmap, the project aims to establish foundational methodological elements for assessing the potential adverse effects of dietary xenobiotics on the gut microbiome and host health through systematic available evidence appraisal and meta-synthesis. In particular, the project will systematically evaluate promising microbiome-relevant biomarkers related to key health endpoints (e.g. intestinal barrier integrity, inflammatory responses, microbiome metabolic capacity, immune system effects, microbiome composition and function) and the suitability of available in vitro models (e.g., SHIME, triple co-culture, MBRA, organoids). It will prioritise optimal biomarker-in vitro model pairings based on regulatory science applicability and feasibility, and identify appropriate analytical methods (including omics-based approaches) for each combination. The outcomes will provide an evidence-based prioritisation framework and feasibility assessment to inform potential follow-up experimental validation of the prioritised biomarker-in vitro model combinations and support the possible integration of microbiome data into risk assessment.
Doc Title: Evaluation of microbiome-relevant biomarkers and in vitro models for xenobiotic risk assessment
Contract Type: services
